Description
Dosage Forms & Strengths
Atovaquone/Proguanil Tablets
– Strength: 62.5mg atovaquone / 25mg proguanil
Malaria Prophylaxis
– For <11 kg: Safety and efficacy not established
– For 11-20 kg: 62.5 mg atovaquone / 25 mg proguanil (1 pediatric tablet) orally once daily
– For 21-30 kg: 125 mg atovaquone / 50 mg proguanil (2 pediatric tablets) orally once daily
– For 31-40 kg: 187.5 mg atovaquone / 75 mg proguanil (3 pediatric tablets) orally once daily
– For >40 kg: 250 mg atovaquone / 100 mg proguanil (1 adult tablet) orally once daily, initiated 1-2 days before travel to the malaria-endemic area, continued until 7 days after return
Treatment
– For <5 kg: Safety and efficacy not established
– For 5-8 kg: 125 mg atovaquone / 50 mg proguanil (2 pediatric tablets) orally once daily for 3 days
– For 9-10 kg: 187.5 mg atovaquone / 75 mg proguanil (3 pediatric tablets) orally once daily for 3 days
– For 11-20 kg: 250 mg atovaquone / 100 mg proguanil (1 adult tablet) orally once daily for 3 days
– For 21-30 kg: 500 mg atovaquone / 200 mg proguanil (2 adult tablets) orally once daily for 3 days
– For 31-40 kg: 750 mg atovaquone / 300 mg proguanil (3 adult tablets) orally once daily for 3 days
– For >40 kg: 1 g atovaquone / 400 mg proguanil (4 adult tablets) orally once daily for 3 days
Dosing Considerations
– In the event of vomiting within 1 hour of the dose, administer a repeat dose
