Description
Combination of Sitagliptin 50mg and Metformin 850mg
Janumet is a medication that combines two active ingredients, sitagliptin and metformin, which belong to different drug classes:
– Sitagliptin is a DPP-4 inhibitor that helps increase insulin levels after meals and decreases the amount of sugar your body makes.
– Metformin is a biguanide that also helps control blood sugar levels.
Drug Interactions:
Before starting Janumet, it’s crucial to inform your doctor about all medications you are currently taking or plan to take. Certain medications can affect how Janumet works, necessitating adjustments in dosage or more frequent monitoring. Pay special attention if you’re taking:
– Corticosteroids (for conditions like asthma and arthritis).
– Diuretics (increase urine production).
– NSAIDs and COX-2 inhibitors (for pain and inflammation), such as ibuprofen and celecoxib.
– ACE inhibitors and angiotensin II receptor antagonists (for high blood pressure).
– Drugs for asthma).
– Iodinated contrast agents or alcohol-containing medicines.
– Medicines for stomach problems, such as cimetidine.
– Ranolazine (for angina).
– Dolutegravir (for HIV infection).
– Vandetanib (for medullary thyroid cancer).
– Digoxin (for heart problems); its levels may need monitoring.
Dosage and Administration:
– Take Janumet twice daily with meals to help reduce the risk of an upset stomach.
– Your doctor may adjust your dosage to better control your blood sugar levels.
– If you have reduced kidney function, a lower dose may be prescribed.
Pregnancy and Breastfeeding:
– If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using Janumet.
– Avoid taking Janumet if you are pregnant or breastfeeding, as it is not recommended during these periods.
